N-Chlorosuccinimide (NCS)

Flow injection chemiluminescence determination of N-bromosuccinimide and N-chlorosuccinimide.

Immobilized N-Chlorosuccinimide as a Friendly Peptide Disulfide-Forming Reagent

A novel immobilized N-chlorosuccinimide resin was developed for peptide disulfide bond formation in combinatorial libraries. The resin is prepared in a simple two-step process from commercial starting materials. Disulfide formation is initiated by adding a peptide solution to the resin, and excess reagent is removed by a convenient filtration upon completion of disulfide formation. Completion o...

Synthesis of sulfonimidamides from sulfinamides by oxidation with N-chlorosuccinimide

BACKGROUND The synthesis of sulfonimidamides involves the nucleophilic substitution of a sulfonimidoyl chloride with an amine. However, only four chlorinating systems have been reported for the preparation of the sulfonimidoyl chloride intermediates. Whereas some of them have shown a rather limited substrate spectrum, the most versatile and commonly used tert-butyl hypochlorite is known to be e...

The H - NCS bond energy , AHo , ( HNCS ) , AHo , ( NCS ) , and IP ( NCS ) from photoionization mass spectrometric studies of HNCS , NCS , and ( NCS )

The species HNCS and NCS have been studied by photoionization mass spectroscopy. The adiabatic ionization potential (IP) of HNCS is 69.92 eV, the shape of the ion yield.curve near threshold implies a large change in geometry, perhaps to linear HNCS+. Various appearance potentials (AP) from HNCS are determined by a more objective procedure, from which AH>(HNCS)>29.6 kcal/ mol (and very likely >3...

Three new methods for the assay of albendazole using N-chlorosuccinimide

Two titrimetric and one spectrophotometric methods are described for the determination of albendazole in pure form and in formulations. In direct titrimetric procedure (Method A), the drug is titrated directly with N-chlorosuccinimide solution in hydrochloric acid medium using indigo carmine as indicator. In back titrimetry (Method B) the drug is treated with a measured excess of the oxidant in...